Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater

Sterol regulatory-element binding proteins (SREBPs), sirtuin (SIRT1), and liver X receptor ? (LXR?) play important roles in regulating cholesterol metabolism mammals. However, little is known about the relationship between SIRT1, LXR?, SREBP-1 fish. In addition, knowledge of effects salinity on hepatic euryhaline teleosts fragmented. This study revealed that content was significantly different fresh water (FW)- seawater (SW)-acclimated Indian medaka. Gene expression analysis indicated srebp-1 , lxr? sirt1 transcripts were not affected by changes ambient salinity. SREBP-1, but LXR? SIRT1 protein expression, induced FW-acclimated When Vivo-MO inhibited translation, predominantly downregulated FW- SW-acclimated first to show involved biosynthesis Furthermore, knockdown had hmgcr fdps which encode key enzymes biosynthesis. further enhances our livers during acclimation.